The adverse effects of growth hormones, the so-called HGH side effects are also a very interesting and hotly debated topic. HGH does not have the typical side effects of anabolic / androgenic steroids including reduced endogenous testosterone production, acne, hair loss, aggressiveness, elevated estrogen levels in women Virilisierungssymptome and increased water and salt retention. The main side effects that may occur with HGH are an abnormally low concentration of glucose in the blood (hypoglycemia) and an inadequate thyroid function. In some cases antibodies against growth hormones are developed but these are clinically irrelevant. 

What about the horror stories about acromegaly, bone deformities, heart enlargement, organ conditions, gigantism, and early death? To answer these questions, a clear distinction be made between individuals before and after puberty. The growth plates in humans continue to grow until puberty. After puberty neither an endogenous hypersecretion of growth hormones nor an excessive exogenous supply of STH generate additional growth in length of bones. Abnormal size (gigantism) initially goes hand in hand with remarkable body strength and muscular hardness in those affected, but later it ends in weakness and death, it remains untreated. Again, this is only possible in humans before puberty, which also still suffer from an inadequate gonadal function (hypogonadism). In addition, people can suffer with endogenous hypersecretion after puberty and whose normal growth is completed, in acromegaly. The bone will continue, but not longer. There is a progressive growth of the hands and feet and enlargement of facial features due to the convergence of the lower jaw and nose.

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